

Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells, Fachbücher
The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and t... Mehr erfahren
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The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression. In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the exis.
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Lieferzeit:2-4 Werktage
Marke:VDM