Acute Myelogenous Leukemia, Fachbücher von Judith E., Karp

TABLE OF CONTENTS I. Overview of AML: Francis Giles, MD Anderson II. Molecular Foundations of AML Pathogenesis and Pathophysiology A. Transcriptional Control of Myeloid Differentiation and Transformation: Alan Friedman, Johns Hopkins B. Myelodysplasia-Related AML: Ghulam Mufti, King's College, London, England C. Treatment-Related AML: Michelle LeBeau, University of Chicago D. DNA Damage and Repair: David Steensma and Scott Kaufmann Mayo Clinic E. Apoptosis: Ruben Mesa and Scott Kaufmann, Mayo Clinic F. Drug Resistance Transporters: Douglas Ross, University of Maryland III. Translating Biology into Clinical Application A. Impact of Cytogenetics on Clinical Outcome: David Grimwade, Guy's Hospital, London, England B. APL: A Classic Tale of Bench to Bedside: Martin Tallman, Northwestern C. Molecular Therapeutics of AML: Selected Targeted Approaches Overview: Edward Sausville, University of Maryland FLT3: Mark Levis, Johns Hopkins Farnesyltransferase: Jeffrey Lancet, Moffitt (University of South Florida) Modulating Gene Expression as a Therapeutic Approach: Tamer Fandy, Hetty Carraway, Steven Gore, Johns Hopkins Growth Factor-Based Differentiation: William Matsui, Johns Hopkins D. Stem Cell Transplantation: Richard Jones, Johns Hopkins E. Vaccine Development: Ivan Borrello, Johns Hopkins IV. Special Challenges A. Pediatric AML: Robert Arceci, Johns Hopkins -- pending B. AML in the Elderly: Richard Stone, Dana Farber C. Myeloproliferative Disorders: Jason Gottlib, Stanford D. New Clinical Trials Designs: Elihu Estey, MD Anderson.